Revista do Instituto de Medicina Tropical de São Paulo
versão impressa ISSN 0036-4665
GOMEZ-BANQUERI, H.; GARCIA RUIZ, M. A.; MONTEOLIVA, M. e SANCHEZ-MORENO, M.. The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites. Rev. Inst. Med. trop. S. Paulo [online]. 1987, vol.29, n.4, pp. 200-204. ISSN 0036-4665. http://dx.doi.org/10.1590/S0036-46651987000400003.
The inhibitor effect on the Glycogen synthetase (E.C.184.108.40.206) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics.
Palavras-chave : Glucógeno sintetasa - inhibicion; Parbendazol; Mebendazol; Albendazol; Tiabendaúol; Ascaris suum; Fasciola hepatica; Moniezia expansa.