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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946


PAPAIORDANOU, Priscila Maria de Oliveira et al. Adverse effect of the intermittent use of rifampin tor leprosy treatment. Rev. Inst. Med. trop. S. Paulo [online]. 1988, vol.30, n.5, pp.383-386. ISSN 1678-9946.

The authors present a case of acute renal failure, acute hemolysis and thrombocytopenia due to intermittent use of Rifampin for leprosy. These adverse reactions have rarely been discribed in the medical literature. During follow up there was recovery of renal function and complete remission of the hematological alterations. To our knowledge, this has been the first report of such adverse effects of Rifampin during leprosy therapy in Brazil. Pathogenetic aspects are discussed and current literature is reviewed.

Keywords : Insuficiência renal aguda; Hemólise aguda; Trombocitopenia; Hanseníase.

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