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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
TAFURI, Washington Luiz et al. Optical and electron microscopical studies of canine kidney naturally and experimentally infected with Leishmania (Leishmania) chagasi. Rev. Inst. Med. trop. S. Paulo [online]. 1989, vol.31, n.3, pp.139-145. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46651989000300002.
Two naturally infected dogs (male and fema lei from Teófilo Otoni (MG Brazili were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 106 promastigotes of MHO BR 70 BH46 Leishinania (Leishmanial chagasi strain, endo venous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulo nephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron dense deposits: (3) chronic interstitial nephritis with intense exudation of plasmocytes: (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.
Keywords : Nefropatia parasitária; Leishmania (L.) chagasi; Calazar canino.