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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
CAMPOS, Rubens; AMATO NETO, Vicente; SOUZA, Hertha Barbara Wüllert Telles de and BRAZ, Lucia Maria Almeida. Proposal of a new process for screening of drugs in experimental infection with Trypanosoma cruzi. Rev. Inst. Med. trop. S. Paulo [online]. 1991, vol.33, n.4, pp.325-327. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46651991000400014.
We propose a screening process for detection of therapeutic activity of drugs against experimental infection with Trypanosoma cruzi. It is based on the use of infected tryatominae that are fed on mice which have received the study drug. Blood meals are made at different time schedule in order to adapt with serum drug levels. The digestive tube of the hemyptera will, thus, work as a suitable structure for examination. In a initial observation, benzonidazole was used, and was shown to be only partially active at least in the conditions of this new procedure.
Keywords : Trypanosoma cruzi; Infecção experimental; Tratamento; Triagem de medicamentos.