Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
ADAD, Sheila J.; ANDRADE, Débora Cristiane da Silva; LOPES, Edison Reis and CHAPADEIRO, Edmundo. Contribution to the study of the pathology and pathogenesis of the chagasic megaesophagus . Rev. Inst. Med. trop. S. Paulo [online]. 1991, vol.33, n.6, pp.443-450. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46651991000600004.
Systematized study was made in 56 esophagi of chronic chagasics (17 with and 39 without megas) aiming to: 1) to avaluate the esophageal caliber and thickness ranges; 2) analyse qualitative and quantitatively, the myenteric plexuses, trying to evaluate the relation of their lesions and the development of megaesophagus (ME); 3) study the lesions of the muscularis propria to verify if they contribute or not to the beginning of the process; 4) search for T. cruzi and its eventual relationship with the inflammation; 5) identify the principal mucosal alterations. It was confirmed that the severest lesions were found in the muscularis propria and in the plexures of Auerbach ganglia. In the former, the main alterations were myositis and fibrosis. The myentric plexuses showed inflammation and neuronal depopulation when compared with non-mega chagasic esophagi and even more when compared with the controls. On the other hand, there were normal caliber esophagi with severe denervation. It is possible that several factors may lead to the esophagopathy, especially to the ME. The search for T. cruzi was found positive in four out of eight esophagi with mega and in none of eight chagasic esophagi without mega. Mucosal and submucosal lesions were unremarkable and do not seem to be involved with the development of the process.
Keywords : Doença de Chagas; Tripanossomíase cruzi; Megaesôfago; Acalásia.