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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
RABELLO, Ana Lúcia Teles et al. Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni. Rev. Inst. Med. trop. S. Paulo [online]. 1992, vol.34, n.6, pp.601-608. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46651992000600016.
From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods.
Keywords : Schistosoma mansoni; Stool examination; Egg counts; Rectal biopsy; Oxamniquine.