Revista do Instituto de Medicina Tropical de São Paulo
versão impressa ISSN 0036-4665
SILVA, L.C. da et al. Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-a. Rev. Inst. Med. trop. S. Paulo [online]. 1995, vol.37, n.3, pp. 239-243. ISSN 0036-4665. http://dx.doi.org/10.1590/S0036-46651995000300010.
The response to interferon treatment in chronic hepatitis NANB/C has usually been classified as complete, partial or absent, according to the behavior of serum alanine aminotransferase (ALT). However, a more detailed observation of the enzymatic activity has shown that the patterns may be more complex. The aim of this study was to describe the long term follow-up and patterns of ALT response in patients with chronic hepatitis NANB/C treated with recombinant interferon-a. A follow-up of 6 months or more after interferon-a was achieved in 44 patients. We have classified the serum ALT responses into six patterns and the observed frequencies were as follows: I. Long term response = 9 (20.5%); II. Normalization followed by persistent relapse after IFN = 7 (15.9%); III. Normalization with transient relapse = 5 (11.9%); IV. Temporary normalization and relapse during IFN = 4 (9.1%); V. Partial response (more than 50% of ALT decrease) = 7 (15.9%); VI. No response = 12 (27.3%). In conclusion, ALT patterns vary widely during and after IFN treatment and can be classified in at least 6 types.
Palavras-chave : Chronic hepatitis; Hepatitis C; Antiviral Therapy; Interferon; Response; Relapse.