SciELO - Scientific Electronic Library Online

 
vol.40 número3Virulence Factors IN Fungi OF Systemic MycosesFETO-PLACENTARY PATHOLOGY IN HUMAN PARVOVIRUS B19 INFECTION índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista do Instituto de Medicina Tropical de São Paulo

versión impresa ISSN 0036-4665

Resumen

BARBOSA, Carlos Augusto Lopes; CAMPOS, Dulcinéa Maria Barbosa  y  OLIVEIRA, Jayrson Araújo de. ASSESSMENT OF IVERMECTIN THERAPEUTIC EFFICACY ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN MICE EXPERIMENTALLY INFECTED. Rev. Inst. Med. trop. S. Paulo [online]. 1998, vol.40, n.3, pp. 137-144. ISSN 0036-4665.  http://dx.doi.org/10.1590/S0036-46651998000300002.

In this study we evaluated the potential action of ivermectin on third-stage larvae, both at migratory and encysted phases, in mouse tissues after experimental infection with Lagochilascaris minor. Study groups I and II consisted of 120 mice that were orally administered 1,000 parasite eggs. In order to assess ivermectin action upon migratory larvae, group I (60 mice) was equally split in three subgroups, namely I-A, I-B, and I-C. On the 7th day after inoculation (DAI), each animal from the subgroup I-A was treated with 200 µg/Kg ivermectin while subgroup I-B was given 1,000 µg/Kg, both groups received a single subcutaneous dose. To assess the drug action on encysted larvae, group II was equally split in three subgroups, namely II-A, II-B, II-C. On the 45th DAI each animal was treated with ivermectin at 200 µg/Kg (subgroup II-A) and 1,000 µg/Kg (group II-B) with a single subcutaneous dose. Untreated animals of subgroups I-C and II-C were used as controls. On the 60th DAI all animals were submitted to larva search. At a dose of 1,000 µg/Kg the drug had 99.5% effectiveness on third-stage migratory larvae (subgroup I-B). Ivermectin efficacy was lower than 5% on third-stage encysted larvae for both doses as well as for migratory larvae treated with 200µg/Kg.

Palabras llave : Ivermectin; Lagochilascaris minor; Third-stage larvae.

        · resumen en Portugués     · texto en Inglés