SciELO - Scientific Electronic Library Online

vol.41 issue4Protection of C57BL/10 mice by vaccination with association of purified proteins from Leishmania (Leishmania) amazonensisHepatic regeneration after partial hepatectomy in mice infected with Schistosoma mansoni, at the acute and chronic phases of the disease author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946


MENEZES, Carla M. S. et al. In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence. Rev. Inst. Med. trop. S. Paulo [online]. 1999, vol.41, n.4, pp.249-253. ISSN 1678-9946.

Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.

Keywords : Erythromycin; Modulating effect; Antimalarial activity; Chloroquine P. falciparum resistance.

        · abstract in Portuguese     · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License