Resumen

DUARTE, Lucienir Pains et al. Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae). Rev. Inst. Med. trop. S. Paulo [online]. 2002, vol.44, n.2, pp. 109-112. ISSN 0036-4665.  http://dx.doi.org/10.1590/S0036-46652002000200010.

Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20a-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.

Palabras llave : Austroplenckia populnea; Pentacyclic triterpenes; Anti-trypanosomal activity; Growth inhibition.