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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
PONCE DE LEON, Patricia and VALVERDE, Juana. ABO System: molecular mimicry of Ascaris lumbricoides. Rev. Inst. Med. trop. S. Paulo [online]. 2003, vol.45, n.2, pp.107-108. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46652003000200011.
A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined. Extracts of A. lumbricoides [AE] were prepared by surgical remotion of the cuticle and refrigerated mechanical rupture. Agglutination Inhibition (AI) and Hemoagglutination Kinetics (HK) tests were used with the [AE]. Of the 28 [AE], eight belonged to O group patients, 15 to A group, three to B group and the remaining two to AB children. The AI Test showed A epitopes in two [AE] of group A patients and B epitopes in two [AE] of group B patients. The HK Test showed B antigenic determiners in two [AE] of group B patients and in two [AE] of group AB patients as well as A antigenic determiners in one [AE] of A group patient. Of the 28 [AE] studied in both tests B epitopes were detected in all [AE] from B and AB patients and A epitopes in three of the 15 [AE] of group A patients. The experiments carried out suggest that A. lumbricoides might absorb A and B antigens from the host, and/or modify the cuticular carbohydrates expression as a kind of antigenic mimicry.
Keywords : Ascaris lumbricoides; ABO System; Mimicry.