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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946


SATO, Neuza Satomi et al. Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies. Rev. Inst. Med. trop. S. Paulo [online]. 2003, vol.45, n.6, pp.319-322. ISSN 1678-9946.

A rapid test based on an immunochromatography assay - Determine™ Syphilis TP (Abbott Lab.) for detecting specific antibodies to Treponema pallidum was evaluated against serum samples from patients with clinical, epidemiological and serological diagnosis of syphilis, patients with sexually transmitted disease other than syphilis, and individuals with negative serology for syphilis. The Determine™ test presented the sensitivity of 93.6%, specificity of 92.5%, and positive predictive value and negative predictive value of 95.2% and 93.7%, respectively. One serum sample from patient with recent latent syphilis showed a prozone reaction. Determine™ is a rapid assay, highly specific and easy to perform. This technique obviates the need of equipment and its diagnostic features demonstrate that it may be applicable as an alternative assay for syphilis screening under some emergency conditions or for patients living in remote localities.

Keywords : Syphilis; Treponema pallidum; Immunochromatography assay; Antibody; Rapid test.

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