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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
SEVERO, Luiz Carlos; LEMOS, Antonio Carlos Moreira and LACERDA, Heloisa Ramos. Mediastinal histoplasmosis: report of the first two Brazilian cases of mediastinal granuloma. Rev. Inst. Med. trop. S. Paulo [online]. 2005, vol.47, n.2, pp. 103-105. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46652005000200009.
This report documents the first two Brazilian cases of mediastinal granuloma due to histoplasmosis, presenting selected aspects on the diagnosis. Tissue samples revealing histoplasmosis were obtained from each of the patients by mediastinoscopy and thoracotomy. In the second patient, a subcarinal calcified mass eroded into the bronchial tree, leading to secondary bilateral aspiration pneumonitis one week after thoracotomy. Although rare, histoplasmosis should be included in the differential diagnosis of mediastinal granuloma, specially if there are calcifications greater than 10 mm in dimension.
Keywords : Histoplasmosis; Histoplasma capsulatum var. capsulatum; Mediastinal histoplasmosis; Mediastinal granuloma.