SciELO - Scientific Electronic Library Online

 
vol.50 issue2Self-diagnosis of active head lice infestation by individuals from an impoverished community: high sensitivity and specificitySeroconvertion to hepatitis B vaccine after weight reduction in obese non-responder author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista do Instituto de Medicina Tropical de São Paulo

Print version ISSN 0036-4665

Abstract

TUON, Felipe Francisco et al. Hemophagocytic syndrome associated with hepatitis A: case report and literature review. Rev. Inst. Med. trop. S. Paulo [online]. 2008, vol.50, n.2, pp. 123-127. ISSN 0036-4665.  http://dx.doi.org/10.1590/S0036-46652008000200012.

Virus-Associated Hemophagocytic Syndrome (VAHS) is a severe hematological disorder related to some viral infections. It is an illness characterized by persistent fever, pancytopenia, splenomegaly, hyperferritinemia and, the most important, hemophagocytosis observed in the bone marrow, liver and/or lymph nodes. VAHS associated with hepatitis A virus infection is rarely described, despite the high incidence of this viral infection in the population in general. There is no consensus in the literature regarding the optimal treatment of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed, including description of cases of VAHS related to hepatitis A virus infection found in the medical literature.

Keywords : Hemophagocytic syndrome; Hemophagocytosis; Viral-associated hemophagocytic syndrome; Hepatitis A virus; Intravenous immunoglobulin; Thrombocytopenia; Pancytopenia.

        · abstract in Portuguese     · text in English     · pdf in English