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Revista do Instituto de Medicina Tropical de São Paulo
On-line version ISSN 1678-9946
DINELLI, Maria Isabel Saraiva and MORAES-PINTO, Maria Isabel de. Seroconvertion to hepatitis B vaccine after weight reduction in obese non-responder. Rev. Inst. Med. trop. S. Paulo [online]. 2008, vol.50, n.2, pp. 129-130. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46652008000200013.
Decreased responses to hepatitis B vaccine have been associated with some host conditions including obesity. Susceptible non-responders to a primary three-dose vaccine series should be revaccinated. Those who maintain a non-responder condition after revaccination with three vaccine doses are unlikely to develop protection using more doses. This is a description of an obese woman who received six doses of hepatitis B vaccine and persisted as a non-responder. She was submitted to a vertical banded gastroplasty Roux-en-Y gastric bypass Capellas's technique. After weight reduction, she received three additional doses of vaccine and seroconverted. Further studies should help clarify the need to evaluate antibody levels and eventually revaccinate the increasing population of individuals who undergo weight reduction.
Keywords : Hepatitis B; Vaccine; Non-responder; Obesity; Gastroplasty.