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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946


REGO, Moacyr Jesus Barreto de Melo et al. Evaluation of WGA and Concanavalin A (Con A) lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system. Rev. Inst. Med. trop. S. Paulo [online]. 2013, vol.55, n.3, pp.213-215. ISSN 1678-9946.


Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells.


Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry.


WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed.


WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system.

Keywords : Lectin histochemistry; Colonic lesions; Schistosomiasis.

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