SciELO - Scientific Electronic Library Online

 
vol.55 issue3Histoplasmosis presenting with multiple pulmonary nodules. A case mimicking radiological features of pulmonary metastasis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Abstract

REGO, Moacyr Jesus Barreto de Melo et al. Evaluation of WGA and Concanavalin A (Con A) lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system. Rev. Inst. Med. trop. S. Paulo [online]. 2013, vol.55, n.3, pp.213-215. ISSN 1678-9946.  https://doi.org/10.1590/S0036-46652013000300014.

Introduction:

Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells.

Methods:

Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry.

Results:

WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed.

Conclusions:

WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system.

Keywords : Lectin histochemistry; Colonic lesions; Schistosomiasis.

        · abstract in Portuguese     · text in English     · English ( pdf )