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Revista da Sociedade Brasileira de Medicina Tropical
On-line version ISSN 1678-9849
SAMPAIO, Raimunda Nonata Ribeiro and MARSDEN, Phillip Davis. Tratamento da forma mucosa de leishmaniose sem resposta a glucantime, com anfotericina B liposomal. Rev. Soc. Bras. Med. Trop. [online]. 1997, vol.30, n.2, pp.125-128. ISSN 1678-9849. http://dx.doi.org/10.1590/S0037-86821997000200007.
We treated six patients with mucosal leishmaniasis who failed to respond to glucantime (20mg/kg/day) with ambisome (2-5 grams total dose). The daily dose was 2-3mg/kg/day given for a minimum of 20 days. After 26-38 months of follow up, five patients were clinically cured. One relapsed after six months. No side effects of therapy were observed apart from headache after injection. Ambisome is a therapeutic option for patients with mucosal leishmaniasis unresponsive to antimonials.
Keywords : Mucosal leishmaniasis; Leishmania (Viannia) braziliensis; Amphotericin B liposome.