Abstract

RASSI, Anis et al. An attempt of specific treatment by means of ticlopidine of patients with chronic phase of Chagas' disease. Rev. Soc. Bras. Med. Trop. [online]. 2000, vol.33, n.2, pp. 225-226. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822000000200012.

In a previous study, ticlopidine decreased the parasitemy and mortality of mice infected by Trypanosoma cruzi. Therefore, this drug was administered to 12 patients with Chagas' disease, in the chronic phase. For 90 days, 150, 200 or 250mg were utilized according to whether the recipients were children, adolescents or adults, respectively. A fully unsuccessful outcome was documented, both sorologically as well as parasitologically.

Keywords : Chronic phase of Chagas' disease; Ticlopidine; Specific treatment.