SciELO - Scientific Electronic Library Online

 
vol.33 issue4Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azarMaternal and child intestinal parasitism and breast-feeding author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

PEREIRA, Valéria R.A. et al. Immunodiagnosis of chronic Chagas' disease using the Tc 46 and Tc 58 antigens. Rev. Soc. Bras. Med. Trop. [online]. 2000, vol.33, n.4, pp. 367-370. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822000000400006.

The polypeptides of 46 and 58kDa were recognized in different T. cruzi strains (Y, WSL and Colombiana) by serum of all chagasic patients studied. These polypeptides were isolated from T. cruzi Y strain and used in ELISA. The sensitivity and specificity were 97.6% [CI 95%: 86-100%] and 100% [CI 95%: 89.3-100%], respectively when Tc 46 was used. When Tc 58 was used the sensitivity and specificity were 100% [CI 95%: 89.6-100%] and 90.2% [CI 95%: 75.9-96.8%], respectively.

Keywords : T. cruzi; Insoluble antigens; Immunodiagnosis; Chagas' disease.

        · abstract in Portuguese     · text in English     · pdf in English