Revista da Sociedade Brasileira de Medicina Tropical
versión impresa ISSN 0037-8682
CAVASINI, Carlos Eugênio et al. Duffy blood group genotypes among malaria patients in Rondônia, Western Brazilian Amazon. Rev. Soc. Bras. Med. Trop. [online]. 2001, vol.34, n.6, pp. 591-595. ISSN 0037-8682. http://dx.doi.org/10.1590/S0037-86822001000600016.
We have compared Duffy blood group genotype distribution, as determined by polymerase chain reaction with allele-specific primers, in 68 Plasmodium vivax-infected patients and 59 non-vivax malaria controls from Rondônia, Brazil. Homozygosity for the allele Fy, which abolishes Duffy antigen expression on erythrocytes, was observed in 12% non-vivax controls but in no P. vivax patient. However, no significant association was found between Fy heterozygosity and protection against P. vivax. The Fyx allele, which has recently been associated with very weak erythrocyte expression of Duffy antigen, was not found in local P. vivax patients.
Palabras llave : Plasmodium vivax; Malaria; Duffy antigen; Genotypes; Brazilian Amazon.