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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682On-line version ISSN 1678-9849

Abstract

MARTINS, Luisa Caricio; CORVELO, Tereza Cristina de Oliveira; OTI, Henrique Takeshi  and  BARILE, Katarine Antônia dos Santos. Seroprevalence of antibodies against the CagA antigen the Helicobacter pylori in patients with gastric ulcer in the North region of Brazil. Rev. Soc. Bras. Med. Trop. [online]. 2002, vol.35, n.4, pp.307-310. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822002000400005.

Helicobacter pylori is a pathogenic agent with a worldwide distribution and is involved in the development of many gastrointestinal diseases. Nowadays infection with the virulent strain CagA+ of H. pylori is considered one of the main etiological factors in the development of gastric ulcer. Based on this information, we investigated the seroprevalence of virulent strains among patients with gastric ulcer from one region, using serologic tests to detect antibodies against H. pylori and CagA protein. Infection by the virulent strain was found in 82% (40/55) of the patients, and among these, 89% (40/45) presented an increased degree of inflammation in the gastric mucosa, with a dense infiltration of leukocytes in the tissue, which probably favored the formation of gastric ulcer. We concluded that the presence of the virulent strain is related to the development of an increased inflammation in the gastric mucosa.

Keywords : Helicobacter pylori; Gastric ulcer; CagA protein; Serological analyses.

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