SciELO - Scientific Electronic Library Online

 
vol.35 número5Epidemiological and clinical study of 332 cases of cutaneous leishmaniasis in the north of Parana State from 1993 to 1998Outbreak of aggressions and transmission of rabies in human beings by vampire bats in northeastern Brazil índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista da Sociedade Brasileira de Medicina Tropical

versión impresa ISSN 0037-8682

Resumen

GOULART, Isabela Maria Bernades et al. Adverse effects of multidrug therapy in leprosy patients: a five-year survey at a Health Center of the Federal University of Uberlândia. Rev. Soc. Bras. Med. Trop. [online]. 2002, vol.35, n.5, pp. 453-460. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822002000500005.

The introduction of multidrug therapy (WHO/MDT) - composed by the drugs dapsone, clofazimine and rifampicin has enabled the cure of Hansen's disease, however, the adverse effects of these drugs were not given priority by the health team. Aiming to determine MDT's adverse effects' magnitude and relate them to the non-adhesion of patients to the treatment, a study of 187 charts of patients treated with MDT from January of 1995 to May 2000, was carried out at a Health Center of the Federal University of Uberlândia. Side effects were recorded in 71 patients' charts. Among the 113 side effects found, 80 (70.7%) were related to dapsone, 7 (6.2%) were caused by rifampicin and 26 (20.5%) were attributed to clofazimine. These effects induced 28 (14.9%), patients to change the therapeutic scheme, representing 39.4% from the 71 patients with adverse effects. Throughout this study, the importance is discussed of considering MDT's adverse effects when training the health team to heighten the patient's adhesion to the treatment and thereby collaborating to eliminate Hansen's disease as a public health problem.

Palabras llave : Hansen's disease; Adverse effects; Multidrug therapy; Adhesion to treatment.

        · resumen en Portugués     · texto en Portugués     · pdf en Portugués