SciELO - Scientific Electronic Library Online

 
vol.36 issue3Parasitological study with faecal samples of stray and domiciliated cats (Felis catus domesticus) from the Metropolitan Area of Rio de Janeiro, BrazilCulicidae insect fauna from rural zone in Amazonas State with incidence of sylvatic yellow fever author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

SILVA, Luciana M.; MENEZES, Rejane M. C.; OLIVEIRA, Sheilla Andrade de  and  ANDRADE, Zilton A.. Chemotherapeutic effects on larval stages of Schistosoma mansoni during infection and re-infection of mice. Rev. Soc. Bras. Med. Trop. [online]. 2003, vol.36, n.3, pp. 335-341. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822003000300004.

The sensitivity of the larval stages of Schistosoma mansoni to chemotherapy with praziquantel and oxamniquine was tested in mice during primary and secondary infections and after different intervals from cercarial exposure. Worm recovery by perfusion of the porto-mesenteric system, followed by counting and a morphometric study of the parasite, allowed the conclusion that the relative resistance of the larval stages of S. mansoni to schistosomicide drugs, demonstrated in primary infections, also persists when the host is already infected. This indicates that a therapeutic failure may result when an infected host is treated some time after being re-infected, because of the presence of migrating, drug-resistant, immature forms of the parasite.

Keywords : Schistosoma mansoni; Larval stages; Praziquantel; Oxamniquine.

        · abstract in Portuguese     · text in English     · pdf in English