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Revista da Sociedade Brasileira de Medicina Tropical
On-line version ISSN 1678-9849
SAMPAIO, Raimunda Nonata Ribeiro et al. Terbinafine in vivo inefficacy on cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis in C57BL/6 mice. Rev. Soc. Bras. Med. Trop. [online]. 2003, vol.36, n.4, pp.531-533. ISSN 1678-9849. http://dx.doi.org/10.1590/S0037-86822003000400018.
The efficiency of terbinafine was tested in C57BL/6 mice inoculated with the Leishmania (Leishmania) amazonensis strain MHOM/BR/PH8. The mice were administered: terbinafine at a dose of 100mg/kg/d by via oral; 0.9% saline solution orally as the control; and subcutaneous sodium stibogluconate 400mg SbV/kg/d as gold standard, for 20 days. Terbinafine was demonstrated to be ineffective when compared to the controls, using clinical and parasitological parameters and the limiting dilution assay.
Keywords : Leishmaniasis; Terbinafine; Treatment.