SciELO - Scientific Electronic Library Online

 
vol.38 issue2Immunoglobulin isotype and IgG subclass profiles in american tegumentary leishmaniasisVisceral leishmaniasis: a study on phlebotomine sand flies and canine infection in Montes Claros, State of Minas Gerais author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

CAMPOS, Rozália Figueira et al. Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II). Rev. Soc. Bras. Med. Trop. [online]. 2005, vol.38, n.2, pp. 142-146. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822005000200003.

Susceptibility to chemotherapy with benznidazole was investigated of 5 clones isolated from the 21 SF strain (biodeme Type II, Trypanosoma cruzi II). Swiss mice were infected with the parental strain for each clone and submitted to chemotherapy with benznidazole (100mg/kg/day during 90 days). Treatment determined negativity of the parasitemia. Cure rates were evaluated by parasitological cure tests. Serology was evaluated for treated animals (titers from negative to 1:640) and untreated controls (1:160 to 1:640). Cure rates varied from 30 to 100% for the 5 clones, and were 25% for the parental strain. Results suggested that the variability of response to treatment of the clonal populations of Trypanosoma cruzi II strains is responsible for the high variation in the response to chemotherapy with benznidazole and nifurtimox by strains of this biodeme.

Keywords : Trypanosoma cruzi; Trypanosoma cruzi II; Biodeme Type II; Clones; Benznidazole; Chemotherapy.

        · abstract in Portuguese     · text in English     · pdf in English