SciELO - Scientific Electronic Library Online

 
vol.40 issue1Population parameters for Triatoma sordida Stal, 1859: the most frequent vector for Chagas disease in the Triângulo Mineiro (Heteroptera, Triatominae)Sociodemographic, epidemiological and behavioral profile of women infected with HTLV-1 in Salvador, Bahia, an endemic area for HTLV author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

COELHO-DOS-REIS, Jordana Grazziela Alves  and  GRUPO INTERDISCIPLINAR DE PESQUISAS EM HTLV et al. Evaluation of the performance of immunological parameters as indicators for clinical progression of chronic HTLV-1 infection. Rev. Soc. Bras. Med. Trop. [online]. 2007, vol.40, n.1, pp. 29-36. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822007000100006.

This study evaluated the performance of single and combined laboratory parameters, B-lymphocyte percentages (%LB), T/B cell ratio and %CD8+HLA-DR+/CD8+, to differentiate asymptomatic cases (AS) from HAM/TSP patients (HT) within a population of HTLV-1 seropositive cases. Percentage indices demonstrated that each parameter alone presented moderate performance, with co-negativity of 83 and 91% for %LB and T/B cell ratio, respectively, and co-positivity of 78% for %CD8+HLA-DR+/CD8+. Combined analysis (%CD8+HLA-DR+/CD8+ and T/B cell ratio) did not show any substantial performance enhancement (co-positivity = 75% and co-negativity = 74%). Likelihood ratio analysis using different value ranges for the separate parameters revealed that HTLV-1 seropositive cases with %LB<7%, T/B cell ratio>11 and %CD8+HLA-DR+/CD8+>70% would have, respectively, 11, 19 and 10 times greater chance of belonging to the HT group. Therefore, use of these phenotypic indicators as complementary laboratory methods for monitoring the clinical progression of chronic HTLV-1 infection is recommended.

Keywords : HTLV-1; Immunophenotyping; Performance indices; Morbidity indicators.

        · abstract in Portuguese     · text in Portuguese     · pdf in Portuguese