Abstract

COSTA FILHO, Arnoldo Velloso da; LUCAS, Íris Campos  and  SAMPAIO, Raimunda Nonata Ribeiro. Comparative study between oral miltefosine and parenteral N-metil glucamine antimoniate for the treatment of experimental leishmaniasis caused Leishmania (Leishmania) amazonensis. Rev. Soc. Bras. Med. Trop. [online]. 2008, vol.41, n.4, pp. 424-427. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822008000400022.

Twenty-five mice were infected with Leishmania amazonensis and treated with glucamine and oral miltefosine. The criteria used were pad measurements and investigations of amastigotes and cultures after treatment. Measurements: miltefosine 2.43 mm and glucamine 3.46 mm (p: 0.05). Miltefosine smears and cultures were negative. Glucamine produced two positive smears and the cultures were positive (p < 0.05). Miltefosine was similar to or better than glucamine.

Keywords : Miltefosine; Cutaneous leishmaniasis; Cutaneous leishmaniasis; Therapy.