SciELO - Scientific Electronic Library Online

 
vol.42 issue1Dengue in children: clinical and epidemiological characteristics, Manaus, State of Amazonas, 2006 and 2007Prevalence of human T-cell lymphotropic virus (HTLV-1/2) infection among puerperae in Cuiabá, Mato Grosso, 2006 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

MOTA, Licia Maria Henrique da et al. Vaccination against yellow fever among patients on immunosuppressors with diagnoses of rheumatic diseases. Rev. Soc. Bras. Med. Trop. [online]. 2009, vol.42, n.1, pp. 23-27. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822009000100006.

Yellow fever is endemic in some countries. The anti-yellow fever vaccine is the only effective means of protection but is contraindicated for immunocompromised patients. The aim of this paper was to report on a case series of rheumatological patients who were using immunosuppressors and were vaccinated against this disease. This was a retrospective study by means of a questionnaire applied to these patients, who were vaccinated 60 days before the investigation. Seventy patients of mean age 46 years were evaluated. Most of them were female (90%). There were cases of rheumatoid arthritis (54), systemic lupus erythematosus (11), spondyloarthropathy (5) and systemic sclerosis (2). The therapeutic schemes included methotrexate (42), corticosteroids (22), sulfasalazine (26), leflunomide (18), cyclophosphamide (3) and immunobiological agents (9). Sixteen patients (22.5%) reported some minor adverse effect. Among the eight patients using immunobiological agents, only one presented a mild adverse effect. Among these patients using immunosuppressors, adverse reactions were no more frequent than among immunocompetent individuals. This is the first study on this topic.

Keywords : Yellow fever; Vaccine; Rheumatological diseases; Immunosuppressed patients; Immunobiological agents.

        · abstract in Portuguese     · text in Portuguese     · pdf in Portuguese