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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682On-line version ISSN 1678-9849


SOUZA, Valdênia Maria Oliveira  and  MACEDO, Mahasti Sahihi. Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice. Rev. Soc. Bras. Med. Trop. [online]. 2009, vol.42, n.3, pp.345-347. ISSN 0037-8682.

High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.

Keywords : Ascaris suum; Delayed-type hypersensitivity; Immunosuppression; IFN-γ-deficient mice; Neutrophil.

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