Revista da Sociedade Brasileira de Medicina Tropical
Print version ISSN 0037-8682
FREITAS, Jaqueline Aparecida Gleice de; PRUDENTE, Mariana Félix de Souza and CARVALHAES, Mara Silvia. Experimental lagochilascariosis in X-chromosome-linked immunodeficient mice. Rev. Soc. Bras. Med. Trop. [online]. 2009, vol.42, n.4, pp. 381-385. ISSN 0037-8682. http://dx.doi.org/10.1590/S0037-86822009000400005.
Lagochilascaris minor is the etiological agent of lagochilascariosis, a disease that affects the neck region and causes exudative abscesses, with eggs, adult parasites and L3/L4 larvae in the purulent exudates. Mice are now considered to be intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-deficient mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (xid) mice. BALB.xid-infected mice showed lower numbers of larvae. Third-stage larvae, fourth-stage larvae and adult parasites were found in both strains. BALB/c mice produced IgM, IgG, IgA and IgE against the crude extract and secreted/excreted antigens of the parasite. On the other hand, BALB.xid mice did not produce IgM and produced lower levels of IgG and IgA, and similar quantities of IgE.
Keywords : B1 cells; BALB.xid mice; Lagochilascaris minor; Immunoglobulin.