SciELO - Scientific Electronic Library Online

vol.42 issue6Study on the transmission of American cutaneous leishmaniasis in the Federal DistrictSystemic mycosis: factors associated with death among patients infected with the human immunodeficiency virus, Cuiabá, State of Mato Grosso, Brazil, 2005-2008 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682


PEDROSO, Vinicius Sousa Pietra; VILELA, Márcia de Carvalho; PEDROSO, Enio Roberto Pietra  and  TEIXEIRA, Antônio Lúcio. Paracoccidioidomycosis compromising the central nervous system: a systematic review of the literature. Rev. Soc. Bras. Med. Trop. [online]. 2009, vol.42, n.6, pp.691-697. ISSN 0037-8682.

This study is the first systematic review of cases of neuroparacoccidioidomycosis available in the literature. Through searches in the MEDLINE and LILACS databases, 257 cases were found in 81 published studies, mainly after the 1970s-1980s. Approximately 93% of the patients were men, especially farm laborers, with a mean age of 43 years. The characteristic symptoms were motor deficits or intracranial hypertension. The chronic pseudotumoral form predominated. The mean period of evolution was 4.9 months. The lesions were mainly supratentorial (66.8%), located in the frontal and parietal lobes. The diagnosis was determined by biopsy in 57.2% of the cases and neuroimaging methods were used in 64.6% of them. A large proportion of the cases were associated with the pulmonary form of the disease (59.1%). The mortality rate was 44.1%, and 50.1% of the survivors developed sequelae, especially motor impairment. Thus, neuroparacoccidioidomycosis should be considered in the differential diagnosis for expansive and meningoencephalitic processes in the central nervous system, in order to establish early treatment and to avoid disabling sequelae.

Keywords : Paracoccidioidomycosis; Fungal infection; Neuroparacoccidioidomycosis; Central nervous system; Systematic review.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License