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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

VALENTE, Maria do Socorro da Silva  and  VIEIRA, José Luiz Fernandes. Thalidomide used by patients with erythema nodosum leprosum. Rev. Soc. Bras. Med. Trop. [online]. 2010, vol.43, n.2, pp.201-204. ISSN 0037-8682.  https://doi.org/10.1590/S0037-86822010000200019.

INTRODUCTION: Thalidomide is a drug currently used in Brazil for treating erythema nodosum leprosum. METHODS: This was a prospective study to follow up clinical evolution, record adverse events and determine plasma thalidomide levels from a dose of 100 mg/day, among 20 patients with clinical manifestations of erythema nodosum leprosum, divided into two groups: during or after leprosy multidrug therapy. RESULTS: No significant differences between the groups were seen during the study, either in relation to favorable clinical evolution among the patients (70% and 90%), or in relation to the adverse events recorded, which were dizziness and somnolence. The plasma thalidomide levels on D7 and D14 were 0.82 ± 0.4μg/ml and 0.79 ± 0.3 μg/ml in group 1 and 0.82 ± 0.4 and 1.55 ± 1.0 in group 2, respectively. CONCLUSIONS: In this sample, the multidrug therapy had no effect on the clinical evolution, incidence of adverse events and plasma thalidomide levels.

Keywords : Thalidomide; Erythema nodosum leprosum; Leprosy.

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