SciELO - Scientific Electronic Library Online

 
vol.43 issue4Spatial analysis on childhood tuberculosis in the state of Espirito Santo, Brazil, 2000 to 2007Epidemiology of extended spectrum β-lactamase producing Enterobacter bacteremia in a brazilian hospital author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

ALMEIDA, Alessandra Maciel et al. The efficacy of adefovir dipivoxil, entecavir and telbivudine for chronic hepatitis B treatment: a systematic review. Rev. Soc. Bras. Med. Trop. [online]. 2010, vol.43, n.4, pp. 440-451. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822010000400021.

INTRODUCTION: Chronic hepatitis B is one of the most frequent infectious disease in the world and represents a serious problem of public health METHODS: A systematic review of randomized clinical trials was conducted to evaluate the efficacy of the nucleoside/nucleotide analogues (adefovir, entecavir and telbivudine) used for the treatment of chronic hepatitis B. The databases PubMed and LILACS were consulted, among others RESULTS: Twenty nine articles published between January/1970 to December/2009 were selected CONCLUSIONS: All nucleoside/nucleotide analogues demonstrate upper or similar efficacy to lamivudine. The entecavir can be appropriate for patients with chronic hepatitis B, HBeAg positive and negative treatment-naive as alternative to lamivudine, considering its low potential of viral resistance. The addition of adefovir to lamivudine presented good results in lamivudine resistant patients. The use of entecavir and telbivudine in those patients presents risk of crossed resistance. TBV is one of the most recent antivirals available, but antiviral resistance already documented represents limitation to its use as therapeutic option to LAM. Adverse events of nucleoside/nucleotide analogues were similar in characteristics, gravity and incidence when compared to the lamivudina and placebo.

Keywords : Adefovir dipivoxil; Entecavir; Telbivudine; Chronic hepatitis B; Random and controlled clinical studies.

        · abstract in Portuguese     · text in Portuguese     · pdf in Portuguese