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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

FAGUNDES, Glauco Danielle; TABALIPA, Fábio de Oliveira  and  SILVA, Jane da. Antibody levels in children after 10 years of vaccination against hepatitis B: a brazilian community-based study. Rev. Soc. Bras. Med. Trop. [online]. 2012, vol.45, n.2, pp.260-262. ISSN 0037-8682.  https://doi.org/10.1590/S0037-86822012000200024.

INTRODUCTION: It is known that the hepatitis B (HB) vaccine is effective, but it is alarming that sudden drops of antibody levels may coincide with the onset of adolescence. METHODS: Antibody levels against HB vaccine surface antigen (anti-HBs) and HB vaccine core antigen (anti-HBc) were measured on the blood samples of children with a mean age of 11.4 years. RESULTS: About 54.8% had protective levels of anti-HBs. Of those who were anti-HBc-positive (4.4%), an average of 218.4 anti-HBs mIU/mL was found. CONCLUSIONS: Immunological protection was found in the majority of children. However, more studies are needed to elucidate the heritability of nonresponders and establish strategies against such events.

Keywords : Hepatitis B virus; Vaccination; Anti-HBs; Anti-HBc; HBsAg.

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