- Citado por Google
- Similares en SciELO
- Similares en Google
Revista da Sociedade Brasileira de Medicina Tropical
versión impresa ISSN 0037-8682
RASO, Pedro; RASO, Leonardo Arruda Moraes; MELO, Ferdinan de Almeida y TAFURI, Wagner Luiz. Schistosoma mansoni granuloma in late evolutive phase, in a case of tumoral form in man. Rev. Soc. Bras. Med. Trop. [online]. 2012, vol.45, n.5, pp.627-632. ISSN 0037-8682. http://dx.doi.org/10.1590/S0037-86822012000500016.
INTRODUCTION: Authors describe human schistosomal granuloma in late chronic phase, from the morphological and evolutionary viewpoints. METHODS: The study was based on a histological analysis of two fragments obtained from a surgical biopsy of peritoneum and large intestine of a 42-year-old patient, with a pseudotumoral form mimicking a peritoneal carcinomatosis associated to the schistosomiasis hepatointestinal form. RESULTS: Two hundred and three granulomas were identified in the pseudotumor and 27 in the intestinal biopsy, with similar morphological features, most in the late chronic phase, in fibrotic healing. A new structural classification was suggested for granulomas: zone 1 (internal), 2 (intermediate) and 3 (external). CONCLUSIONS: Regarding granuloma as a whole, we may conclude that fibrosis is likely to be controlled by different and independent mechanisms in the three zones of the granuloma. Lamellar fibrosis in zone 3 seems to be controlled by matrix mesenchymal cells (fibroblasts and myoepithelial cells) and by inflammatory exudate cells (lymphocytes, plasmocytes, neutrophils, eosinophils). Annular fibrosis in zone 2, comprising a dense fibrous connective tissue, with few cells in the advanced phase, would be controlled by epithelioid cells involving zone 1 in recent granulomas. In zone 1, replacing periovular necrosis, an initialy loose and tracery connective neoformation, housing stellate cells or with fusiform nuclei, a dense paucicellular nodular connctive tissue emerges, probably induced by fibroblasts. In several granulomas, one of the zones is missing and granuloma is represented by two of them: Z3 and Z2, Z3 and Z1 or Z2 and Z1 and, ultimately, by a scar.
Palabras clave : Schistosomiasis mansoni; Granuloma; Morphology; Evolution and pseudotumor form; Modulation of granuloma.