Revista da Sociedade Brasileira de Medicina Tropical
versión impresa ISSN 0037-8682
MARTINS, Ronaldo Soares; MACHADO, Juliano Antunes y TEIXEIRA, Rosângela. Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a. Rev. Soc. Bras. Med. Trop. [online]. 2012, vol.45, n.5, pp.655-656. ISSN 0037-8682. http://dx.doi.org/10.1590/S0037-86822012000500023.
The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV) treatment.
Palabras clave : Pegylated interferon alfa-2a; Bronchiolitis obliterans organizing pneumonia; Hepatitis C.