SciELO - Scientific Electronic Library Online

 
vol.45 número5Fatal disseminated strongyloidiasis after kidney transplantation índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista da Sociedade Brasileira de Medicina Tropical

versión impresa ISSN 0037-8682

Resumen

MARTINS, Ronaldo Soares; MACHADO, Juliano Antunes  y  TEIXEIRA, Rosângela. Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a. Rev. Soc. Bras. Med. Trop. [online]. 2012, vol.45, n.5, pp. 655-656. ISSN 0037-8682.  http://dx.doi.org/10.1590/S0037-86822012000500023.

The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV) treatment.

Palabras llave : Pegylated interferon alfa-2a; Bronchiolitis obliterans organizing pneumonia; Hepatitis C.

        · resumen en Portugués     · texto en Inglés     · pdf en Inglés