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Revista da Sociedade Brasileira de Medicina Tropical

Print version ISSN 0037-8682

Abstract

BRAZ, Suellen Carvalho de Moura et al. Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens. Rev. Soc. Bras. Med. Trop. [online]. 2013, vol.46, n.3, pp.362-366.  Epub May 10, 2013. ISSN 0037-8682.  http://dx.doi.org/10.1590/0037-8682-1323-2013.

Introduction

CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease.

Methods

Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for lymphocytes at distinct time points.

Results

It was possible to differentiate clinical forms of chronic Chagas disease at days 3 and 5 according to presence of CD4+CD25+ T cells in cell cultures.

Conclusions

Longer periods of cell culture proved to be potentially valuable for prospective evaluations of CD4+CD25+ T lymphocytes in patients with chronic Chagas disease.

Keywords : Chronic Chagas disease; Recombinant antigens; CD4+CD25+ T lymphocytes.

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