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Short Communications • Rev. Soc. Bras. Med. Trop. 48 (3) • May-Jun 2015 • https://doi.org/10.1590/0037-8682-0309-2014   copy

Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis

Authorship SCIMAGO INSTITUTIONS RANKINGS

INTRODUCTION

: We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis.

METHODS

: This cross-sectional study involved 79 patients infected with Schistosoma mansoni with severe or mild/moderate periportal fibrosis. Serum concentrations of mannose-binding lectin were obtained by enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Higher serum level of mannose-binding lectin was significantly associated with advanced periportal fibrosis.

CONCLUSIONS:

Mannose-binding lectin may contribute to liver pathology in schistosomiasis and may represent a risk factor for advanced periportal fibrosis in the Brazilian population studied.

Schistosomiasis mansoni; Periportal fibrosis; Mannose-binding lectin

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