Abstract
INTRODUCTION:
We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.
METHODS:
This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.
RESULTS:
There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.
CONCLUSIONS:
There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.
Keywords:
Interleukin-10; Periportal fibrosis; Schistosomiasis mansoni
