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Revista da Sociedade Brasileira de Medicina Tropical

versão impressa ISSN 0037-8682versão On-line ISSN 1678-9849

Resumo

MARIO, Débora Nunes et al. Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex. Rev. Soc. Bras. Med. Trop. [online]. 2017, vol.50, n.4, pp.554-557. ISSN 0037-8682.  http://dx.doi.org/10.1590/0037-8682-0171-2016.

INTRODUCTION:

We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.

METHODS:

Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen.

RESULTS:

Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species.

CONCLUSIONS:

Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.

Palavras-chave : Sporotrichosis; Antioxidant enzymes; Oxidative stress.

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