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Short Communication • Rev. Soc. Bras. Med. Trop. 52 • 2019 • https://doi.org/10.1590/0037-8682-0182-2018   copy

Biofilm formation by blood isolates of Candida parapsilosis sensu stricto in the presence of a hyperglycidic solution at comparable concentrations of total parenteral nutrition

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Administration of total parenteral nutrition (TPN) via catheters increases the risk for candidemia from Candida parapsilosis.

METHODS:

C. parapsilosis sensu stricto blood isolates were evaluated for ability total biomass biofilm formation and morphogenesis in presence of glucose at TPN equivalent concentrations.

RESULTS:

Biofilms were increased at high glucose concentrations (25-30%) compared to the control medium. Significant increase in filamentous forms was observed in cultures with 30% glucose.

CONCLUSIONS:

Biofilm formation by C. parapsilosis sensu stricto in hyperglycidic medium may contribute to its pathogenic potential for fungemia related to TPN catheters.

Keywords:
Candida parapsilosis; Biofilm; Glucose; TPN

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