Congenital Chagas disease: alert of research negligence

Dias, Nayra; Carvalho, Bruna de; Nitz, Nadjar; Hagström, Luciana; Vital, Tamires; Hecht, Mariana

doi:10.1590/0037-8682-0069-2018

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Short Communication • Rev. Soc. Bras. Med. Trop. 52 • 2019 • https://doi.org/10.1590/0037-8682-0069-2018 copy

Congenital Chagas disease: alert of research negligence

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Chagas disease (CD), a neglected endemic disease in Latin America, has acquired new epidemiological characteristics with an increase in the importance of alternative transmission routes such as congenital transmission. We evaluated the scientific research on this subject.

METHODS:

We searched the Scielo, BVS, and PubMed databases from 2006 to 2017.

RESULTS:

We identified a small number of published articles, mostly in journals with an impact factor less than 3.0. Studies on human congenital transmission of CD were carried out in only seven different countries.

CONCLUSIONS:

Our data highlight the lack of research on congenital CD.

Keywords:
Congenital Chagas disease; Publications; Negligence

Reference	Article	Journal/impact factor	Country	Research time span
Murcia et al., 2017	Treatment of Infected Women of Childbearing Age Prevents	The Journal of	Spain	2013-2015
	Congenital Trypanosoma cruzi Infection by Eliminating the	Infectious
	Parasitemia Detected by PCR	Diseases/6.723
Buekens et al., 2017	Congenital Transmission of Trypanosoma cruzi in Argentina,	The American Journal	Mexico, Honduras,	2011-2014
	Honduras, and Mexico: An Observational Prospective Study	of Tropical Medicine and Hygiene/2.456	and Argentina
Montes- Rincón et al., 2016	Trypanosoma cruzi seroprevalence in pregnant women and	Journal Acta	Mexico	2014-2015
	screening by PCR and microhaematocrit in newborns from	Tropica/2.380
	Guanajuato, Mexico
Vargas et al., 2015	Seroprevalence of Trypanosoma cruzi Infection in	The American Journal	Ecuador	2012
	Schoolchildren and in Pregnant Women from an Amazonian	of Tropical Medicine
	Region in Orellana Province, Ecuador	and Hygiene/2.456
Kaplinski et al., 2015	Sustained Domestic Vector Exposure Is Associated with	Clinical Infectious	Bolivia	2010-2013
	Increased Chagas Cardiomyopathy Risk but Decreased	Diseases/8.736
	Parasitemia and Congenital Transmission Risk Among Young
	Women in Bolivia
Volta et al., 2015	Diagnosis of congenital Trypanosoma cruzi infection: A	Journal Acta	Argentina (Buenos	2008-2011
	serologic test using Shed Acute Phase Antigen (SAPA) in	Tropica/2.380	Aires)
	mother-child binomial samples
Luquetti et al., 2015	Congenital transmission of Trypanosoma cruzi	Memórias do Instituto	Brazil	1994-2014
	in central Brazil. A study of 1,211 individuals born to infected mothers	Oswaldo Cruz/1.789
Rendell et al., 2015	Trypanosoma cruzi-Infected Pregnant Women without Vector Exposure Have Higher	PLOS One/4.411	Bolivia	2010-2011
	Parasitemia Levels: Implications for Congenital Transmission Risk
Moscatelli et al., 2015	Urban Chagas disease in children and women in primary care	Memórias do Instituto	Argentina (Buenos	2005-2007
	centres in Buenos Aires, Argentina	Oswaldo Cruz/1.789	Aires)
Soriano-Arandes et al., 2014	Controlling congenital and paediatric Chagas disease through	BMC Public	Spain	2011
	a community health approach with active surveillance and	Health/2.209
	promotion of paediatric awareness
Fabbro et al., 2014	Trypanocide treatment of women infected with Trypanosoma	PLOS Neglected	Argentina	2012-2013
	cruzi and its effect on preventing congenital Chagas	Tropical Disease/4.446
Velázquez et al., 2014	Predictive role of polymerase chain reaction in the early	Journal Acta	Argentina (Buenos	2004-2009
	diagnosis of congenital Trypanosoma cruzi infection	Tropica/2.380	Aires)
Bua et al., 2013	How to improve the early diagnosis of Trypanosoma cruzi	PLOS Neglected	Argentina	2008-2011
	infection: relationship between validated conventional	Tropical Disease/4.446
	diagnosis and quantitative DNA amplification in congenitally
	infected children
Murcia et al., 2013	Risk factors and primary prevention of congenital Chagas	Clinical Infectious	Spain	2007-2011
	disease in a nonendemic country	Diseases/8.736
Apt et al., 2013	Congenital infection by Trypanosoma cruzi in an endemic	Transactions of the	Chile	2006-2009
	area of Chile: a multidisciplinary study	Royal Society of
		Tropical Medicine and Hygiene/1.631
Duffy et al., 2013	Analytical Performance of a Multiplex Real-Time PCR Assay	PLOS Neglected	Argentina	2011-2012
	Using TaqMan Probes for Quantification of Trypanosoma	Tropical Disease/4.446
	cruzi Satellite DNA in Blood Samples
Ortiz et al., 2012	Presence of Trypanosoma cruzi in pregnant women and	Journal Acta	Chile	2006-2010
	typing of lineages in congenital cases	Tropica/2.380
Otero et al., 2012	Congenital transmission of Trypanosoma cruzi in non-	The American Journal	Spain	2008-2010
	endemic areas: evaluation of a screening program	of Tropical Medicine and Hygiene/2.456
	in a tertiary care hospital in Barcelona, Spain
Clavijo et al., 2012	Prevalence of Chagas disease in pregnant women and	Journal Acta	Bolivia	2006-2008
	incidence of congenital transmission in Santa Cruz de la	Tropica/2.380
	Sierra, Bolivia
Barona-Vilar et al., 2012	Prevalence of Trypanosoma cruzi infection in pregnant Latin	Epidemiology and	Spain	2009-2010
	American women and congenital transmission rate in a non-	Infection/2.515
	endemic area: the experience of the Valencian Health Programme (Spain)
Cardoso et al., 2012	Maternal fetal transmission of Trypanosoma cruzi: a problem	Experimental	Mexico	2006-2008
	of public health little studied in Mexico	Parasitology/1.623
Bisio et al., 2011	Urbanization of congenital transmission of Trypanosoma cruzi:	Transactions of the	Argentina (Buenos	2002-2007
	Prospective polymerase chain reaction study in	Royal Society of	Aires)
	pregnancy	Tropical Medicine and Hygiene/1.631
Flores-Chavez et al., 2011	Surveillance of Chagas disease in pregnant women in	Eurosurveillance/5.98	Spain	2008-2010
	Madrid, Spain, from 2008 to 2010
Romero et al., 2011	Door-to-door screening as a strategy for the detection of	TM & IH. Tropical	Bolivia	2004-2007
	congenital Chagas disease in rural Bolivia	Medicine and International
		Health/2.519
Brutus et al., 2010	Detectable Trypanosoma cruzi Parasitemia during Pregnancy	The American Journal	Bolivia	2004-2005
	and Delivery as a Risk Factor for Congenital Chagas	of Tropical Medicine
	Disease	and Hygiene/2.453
Rissio et al., 2010	Congenital Trypanosoma cruzi Infection. Efficacy of Its	The American Journal	Argentina	1994-2004
	Monitoring in an Urban Reference Health Center in a Non-	of Tropical Medicine
	Endemic Area of Argentina	and Hygiene/2.453
Mallimaci et al., 2010	Early diagnosis of congenital Trypanosoma cruzi infection,	The American Journal	Argentina	2001-2002
	using shed acute phase antigen, in Ushuaia, Tierra del	of Tropical Medicine
	Fuego, Argentina	and Hygiene/2.453
Apt et al., 2010	Vertical transmission of Trypanosoma cruzi in the Province of	Biological	Chile	2006-2008
	Choapa, IV Region, Chile. Preliminary Report (2005-2008)	Research/1.328
Bern et al., 2009	Congenital Trypanosoma cruzi Transmission in Santa Cruz,	Clinical Infectious	Bolivia	2006-2007
	Bolivia	Diseases/8.736
Diez et al., 2008	The Value of Molecular Studies for the Diagnosis of	The American Journal	Argentina	ND
	Congenital Chagas Disease in Northeastern Argentina	of Tropical Medicine and Hygiene/2.453
Brutus et al., 2008	Congenital Chagas disease: Diagnostic and clinical aspects	Journal Acta	Bolivia	2002-2004
	in an area without vectorial transmission, Bermejo, Bolivia	Tropica/2.380
Salas et al., 2007	Risk factors and consequences of congenital Chagas disease	TM & IH. Tropical	Bolivia	2003-2005
	in Yacuiba, south Bolivia	medicine and International Health/2.519

Reference	Sample size (child)	Incidence of congenital	Endemic area?	Maternal nationality
		transmission
Murcia et al., 2017	160	10%	No	Bolivia
Buekens et al., 2017	503	0% Honduras, 6.6%	Yes	Honduras, Argentina, Mexico
		Argentina, and 6.3%
		Mexico
Montes-Rincón et al., 2016	20	20%	Yes	Mexico
Vargas et al., 2015	1649	ND	Yes	Ecuador
Kaplinski et al., 2015	1000	6.8%	Yes	Bolivia
Volta et al., 2015	91	23%	No	69.23% Argentina; 18.68% Bolivia;
				12% Paraguay
Luquetti et al., 2015	1212	1.98%	Yes	Brazil
Rendell et al., 2015	135	11.7%	Yes	Bolivia
Moscatelli et al., 2015	19	Varied	Yes	58.7% Argentina; 17% Bolivia;
				12.4% Peru; 10% Paraguay
Soriano-Arandes et al., 2014	42	6.9%	No	90.5% Bolivia
Fabbro et al., 2014	354	15.3%	No	85% Argentina; 10% Bolivia;
				4% Paraguay
Velázquez et al., 2014	468	10.47%	No	63.5% Argentina; 26.8% Bolivia;
				8.2% Paraguay
Bua et al., 2013	843	11.27%	No	60% Argentina; 35% Bolivia;
				5% Paraguay
Murcia et al., 2013	65	13.8%	No	96.6% Bolivia; 3.4% Paraguay
Apt et al., 2013	4280	4.7%	Yes	Chile
Duffy et al., 2013	74	4.05%	Yes	Argentina
Ortiz et al., 2012	100	3%	Yes	Chile
Otero et al., 2012	20	5%	No	34% Equador; 18% Bolivia; 13% Peru
Clavijo et al., 2012	3579	3.4%	Yes	ND
Barona-Vilar et al., 2012	217	14.15%	No	30% Equador; 21.7% Bolivia,
				17.8% Colombia; 6.4% Argentina
Cardoso et al., 2012	106	4.7%	Yes	ND
Bisio et al., 2011	83	2.6%	No	37.5% Argentina; 24% Bolivia; 23.1%
				Paraguay; 1% Peru;
				14.4% indeterminate
Flores-Chavez et al., 2011	152	5%	No	44.4% Bolivia
Romero et al., 2011	299	7.48%	Yes	Bolivia
Brutus et al., 2010	147	6.1%	Yes	Bolivia
Rissio et al., 2010	4355	4.4%	Yes	Argentina
Mallimaci et al., 2010	68	2.5%	Yes	Argentina
Apt et al., 2010	80	2.5%	Yes	Chile
Bern et al., 2009	138	6.4%	Yes	Bolivia
Diez et al., 2008	121	9.9%	Yes	Argentina
Brutus et al., 2008	231	5.2%	Yes	Bolivia
Salas et al., 2007	2742	5.1%	Yes	Bolivia

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[1] Corresponding author: Mariana Hecht. E-mail:marianahecht@gmail.comOrcid: 0000-0003-3512-7696