Revista do Hospital das Clínicas
versão On-line ISSN 1678-9903
CARVALHO, Filomena Marino; CARVALHO, Jesus Paula; MOTTA, Eduardo Vieira da e SOUEN, Jorge. Müllerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer. Rev. Hosp. Clin. [online]. 2000, vol.55, n.1, pp.17-20. ISSN 1678-9903. http://dx.doi.org/10.1590/S0041-87812000000100004.
Müllerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.
Palavras-chave : Uterine adenosarcoma; Breast cancer; Tamoxifen; Uterine sarcoma.