SciELO - Scientific Electronic Library Online

vol.56 número3Experience with the first Internet-based course at the Faculty of Medicine, University of São PauloPrevention of respiratory syncytial virus infections índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


Revista do Hospital das Clínicas

versión On-line ISSN 1678-9903


NUNES, Danilo Ferreira; CARVALHO, Anderson  y  DUARTE, Alberto José da Silva. Activity of natural killer cells during HIV-1 infection in Brazilian patients. Rev. Hosp. Clin. [online]. 2001, vol.56, n.3, pp.75-78. ISSN 1678-9903.

Natural killer cells are increasingly being considered an important component of innate resistance to viruses, but their role in HIV infection is controversial. Some investigators have found that natural killer cells do not confer a protective effect during the progression of HIV disease, whereas others have shown that natural killer cells may be protective and retard the progression of the disease, either through their lytic activity or by a chemokine-related suppression of HIV replication. In this study, we analyzed functional alterations in the activity of natural killer cells during HIV-1 infection using a natural killer cells activity assay with K562 cells as targets. RESULTS: Our results show that the activity of natural killer cells decreases only in the advanced phase of HIV infection and when high (40:1) effector cell-target cell ratios were used. The depression at this stage of the disease may be related to increased levels of some viral factors, such as gp120 or gag, that interfere with the binding capacity of natural killer cells, or to the decreased production of natural killer cells -activity-stimulating cytokines, such as IFN-a and IL-12, by monocytes, a subset of cells that are also affected in the late stage of HIV infection. The data suggest that decreased natural killer cells cell activity may contribute to the severe impairment of the immune system of patients in the late stages of HIV infection.

Palabras clave : HIV infection; Natural killer cells.

        · resumen en Portugués     · texto en Inglés     · Inglés ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons