Revista do Hospital das Clínicas
On-line version ISSN 1678-9903
CASTRO, Ana Paula B Moschione et al. Secondary hypogammaglobilinemia after use of carbamazepine: case report and review. Rev. Hosp. Clin. [online]. 2001, vol.56, n.6, pp.189-192. ISSN 1678-9903. http://dx.doi.org/10.1590/S0041-87812001000600006.
Immunologic disorders related to anticonvulsant therapy have been described in the last three decades, including cellular and humoral alterations that result in recurrent infections; however, the physiopathologic mechanisms are not completely understood. This report describes a patient with complex partial epilepsy and hypogammaglobulinemia while in treatment with carbamazepine, with significant improvement in clinical signs and laboratory tests after substitution to sodium valproate. The authors stress the importance of clinical and laboratory evaluation of patients in continuous anticonvulsant therapy, including immunoglobulins levels and peripheral blood evaluations.
Keywords : Epilepsy; Immunodeficiency; Carbamazepine; Immunoglobulin; Anticonvulsant therapy.