SciELO - Scientific Electronic Library Online

vol.58 issue6Prevalence of antinuclear autoantibodies in the serum of normal blood dornorsA critical review of the possible benefits associated with homeopathic medicine author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista do Hospital das Clínicas

On-line version ISSN 1678-9903


NOVARETTI, Marcia Cristina Zago et al. Hemolytic disease of the newborn due to anti-U. Rev. Hosp. Clin. [online]. 2003, vol.58, n.6, pp.320-323. ISSN 1678-9903.

Anti-U is a rare red blood cell alloantibody that has been found exclusively in blacks. It can cause hemolytic disease of the newborn and hemolytic transfusion reactions. We describe the case of a female newborn presenting a strongly positive direct antiglobulin test due to an IgG antibody in cord blood. Anti-U was recovered from cord blood using acid eluate technique. Her mother presented positive screening of antibodies with anti-U identified at delivery. It was of IgG1 and IgG3 subclasses and showed a titer of 32. Monocyte monolayer assay showed moderate interaction of Fc receptors with maternal serum with a positive result (3.1%). The newborn was treated only with 48 hours of phototherapy for mild hemolytic disease. She recovered well and was discharged on the 4th day of life. We conclude that whenever an antibody against a high frequency erythrocyte antigen is identified in brown and black pregnant women, anti-U must be investigated.

Keywords : Anti-U; Antibody titration; Hemolytic disease of the newborn; Alloantibodies; Direct antiglobulin test; Monocyte monolayer assay.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License