Abstract

BERNIK, Márcio; VIEIRA, Antonio Hélio Guerra  and  NUNES, Paula Villela. Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males. Rev. Hosp. Clin. [online]. 2004, vol.59, n.6, pp. 357-360. ISSN 0041-8781.  http://dx.doi.org/10.1590/S0041-87812004000600008.

PURPOSE: To investigate whether bethanecol chloride may be an alternative for the clinical management of clomipramine-induced orgasmic dysfunction, reported to occur in up to 96% of male users. METHODS: In this study, 12 fully remitted panic disorder patients, complaining of severe clomipramine-induced ejaculatory delay, were randomly assigned to either bethanecol chloride tablets (20 mg, as needed) or placebo in a randomized, double-blind, placebo-controlled, two-period crossover study. A visual analog scale was used to assess severity of the orgasmic dysfunction. RESULTS: A clear improvement was observed in the active treatment period. No placebo or carry-over effects were observed. CONCLUSION: These findings suggest that bethanecol chloride given 45 minutes before sexual intercourse may be useful for clomipramine-induced orgasmic dysfunction in males.

Keywords : Orgasmic dysfunction; Clomipramine; Bethanecol chloride; Panic disorder; Pharmacological treatment.