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Acta Amazonica

versión On-line ISSN 1809-4392


SILVA, Ellen Cristina Costa da; AMORIM, Rodrigo César das Neves; TADEI, Wanderli Pedro  y  POHLIT, Adrian Martin. Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.. Acta Amaz. [online]. 2009, vol.39, n.1, pp. 229-231. ISSN 1809-4392.

Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization.

Palabras clave : Caferana; Simaroubaceae; Quassinoid; Recrystallization.

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