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Acta Amazonica

versão impressa ISSN 0044-5967versão On-line ISSN 1809-4392

Resumo

OLIVEIRA, Viviana Maria Araújo de; CARNEIRO, Ana Lucia Basilio; CAUPER, Glaucia Socorro de Barros  e  POHLIT, Adrian Martin. In vitro screening of Amazonian plants for hemolytic activity and inhibition of platelet aggregation in human blood. Acta Amaz. [online]. 2009, vol.39, n.4, pp.973-980. ISSN 0044-5967.  http://dx.doi.org/10.1590/S0044-59672009000400026.

In the present study, different aerial parts from twelve Amazonian plant species found in the National Institute for Amazon Research's (INPA's) Adolpho Ducke Forest Reserve (in Manaus, Amazonas, Brazil) were collected. Separate portions of dried, ground plant materials were extracted with water (by infusion), methanol and chloroform (by continuous liquid-solid extraction) and solvents were removed first by rotary evaporation, and finally by freeze-drying which yielded a total of seventy-one freeze-dried extracts for evaluation. These extracts were evaluated initially at concentrations of 500 and 100 µg/mL for in vitro hemolytic activity and in vitro inhibition of platelet aggregation in human blood, respectively. Sixteen extracts (23 % of all extracts tested, 42 % of all plant species), representing the following plants: Chaunochiton kappleri (Olacaceae), Diclinanona calycina (Annonaceae), Paypayrola grandiflora (Violaceae), Pleurisanthes parviflora (Icacinaceae), Sarcaulus brasiliensis (Sapotaceae), exhibited significant inhibitory activity towards human platelet aggregation. A group of extracts with antiplatelet aggregation activity having no in vitro hemolytic activity has therefore been identified. Three extracts (4 %), all derived from Elaeoluma nuda (Sapotaceae), exhibited hemolytic activity. None of the plant species in this study has known use in traditional medicine. So, these data serve as a baseline or minimum of antiplatelet and hemolytic activities (and potential usefulness) of non-medicinal plants from the Amazon forest. Finally, in general, these are the first data on hemolytic and inhibitory activity on platelet aggregation for the genera which these plant species represent.

Palavras-chave : Adolpho Ducke Reserve; Chaunochiton kappleri; Diclinanona calycina; Elaeoluma nuda.

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