Jornal Brasileiro de Psiquiatria
Print version ISSN 0047-2085
CHENIAUX, Elie. Treatment of premenstrual dysphoria with antidepressants: review of controlled clinical trials. J. bras. psiquiatr. [online]. 2006, vol.55, n.2, pp. 142-147. ISSN 0047-2085. http://dx.doi.org/10.1590/S0047-20852006000200008.
INTODUCTION: Premenstrual dysphoria (PMD), which affects between 3% and 8% of women during reproductive years, represents a more severe type of premenstrual syndrome. Mood and behavior changes are predominant in PMD. It is believed that there is some kind of link between PMS and mood disorders. OBJECTIVE: Studying the efficacy of antidepressants in PMD. METHODS: We elaborated a review of controlled clinical trials with antidepressants in the treatment of PMD, using the following databases: Medline, LILACS, psycINFO and Cochrane Library. RESULTS: Clomipramine, fluoxetine, sertraline, paroxetine and venlafaxine were superior to placebo in various studies. DISCUSSION: Women with PMD possibly present a serotonergic dysfunction. CONCLUSION: Some antidepressants, specialy SSRIs, seem to be effective in the treatment of PMD.
Keywords : premenstrual syndrome; treatment; antidepressants; review.